Our Story

Ran Ma was studying Biomedical Engineering at Johns Hopkins University and working at Northwestern on the Wounded Warriors Project, a biomask to regenerate the human face for burn victims and war veterans. While working at the wound lab at Northwestern, she learned that there are over 100,000 annual lower limb amputations due to diabetic foot ulcers.

She came up with the initial concept for Siren’s Neurofabric - a seamless, wearable technology - to address this specific, often fatal problem. Ma believes that wearable technology and data are the keys to preventing many health conditions, specifically in the field of chronic disease and aging.

In 2015, at the 7th International Symposium on the Diabetic Foot, Ma crossed paths with Henk Jan Scholten and Jie Fu and together they co-founded Siren in San Francisco.


Siren’s vision is to empower people to avoid complications caused by chronic disease and aging. To this end, Siren develops innovative wearable health technology that seamlessly integrates into the user’s everyday life.

The company’s first product, the Siren Sock and Foot Monitoring System, is designed to proactively track foot temperature. It allows patients and their physicians to monitor for signs of inflammation that have been associated with dangerous conditions such as infections and ulcers¹.


Ran Ma
CEO Ran Ma studied biomedical engineering at Johns Hopkins and worked at Northwestern on the biomask project for wounded veterans. She comes from three generations of doctors. She focuses on the prevention of complications caused by chronic disease and aging.

“If I do my job right, I put my parents out of a job,” Ma jokes. “Less emergencies, less surgeries, and less late stage interventions.”

Jie Fu
CTO Jie Fu has over 10 years of experience in hardware manufacturing and a family history of diabetes. He has designed and manufactured multiple hardware products, and joined the team looking forward to the challenge of developing an innovative and new product that saves lives.

Henk Jan Scholten
COO Henk Jan Scholten has multiple years of experience in the garment manufacturing industry, working for companies such as H&M, Inditex, and Asos. He relishes the opportunity to combine his passion for healthcare with an in-depth knowledge of textiles.


Dr. Alexander M. Reyzelman
Co-Director, UCSF Center for Limb Preservation

Dr. David G. Armstrong
Professor of Clinical Surgery, Keck School of Medicine of USC

Daniel Burnett
Founder & CEO, Theranova

Dan Macklin
Co-founder, SoFi


The work we do is made possible by investors including Khosla Ventures, DCM, Founders Fund, Liquid2, Bragiel Brothers, 500 Startups, Plug and Play, A-Level Capital, Pascal Levy-Garboua, Leo Chan and Julie McDermott.

Research Citations
1. Lavery, Armstrong: Skin Temperature Monitoring Reduces the Risk for Diabetic Foot Ulceration in High-Risk Patients. The American Journal of Medicine 120:1042-1046, 2007.

* Our products and services are only intended to be a health and wellness product and are not intended for use in the diagnosis of disease or other conditions or in the cure, mitigation, treatment or prevention of disease.